Glomerular Filtration Barrier and Mechanism of Proteinuria
نویسندگان
چکیده
منابع مشابه
The Glomerular Filtration Barrier: Components and Crosstalk
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physicochemical and signalling interplay among its three core constituents-the glomerular endothelial cell, the basement membrane and visceral epithelial...
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BACKGROUND Chronic kidney disease (CKD) is associated with substantial burden and is a strong risk factor for cardiovascular disease. However, data on the relationship between CKD and stroke are few and are limited by unreliable or inadequate assessment of renal function. OBJECTIVE To properly assess the relationship between renal insufficiency and stroke in stroke survivors in the United Sta...
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This review focuses on the intricate properties of the glomerular barrier. Other reviews have focused on podocyte biology, mesangial cells, and the glomerular basement membrane (GBM). However, since all components of the glomerular membrane are important for its function, proteinuria will occur regardless of which layer is affected by disease. We review the properties of endothelial cells and t...
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The increasing burden of chronic kidney disease worldwide and recent advancements in the understanding of pathologic events leading to kidney injury have opened up new potential avenues for therapies to further diminish progression of kidney disease by targeting the glomerular filtration barrier and reducing proteinuria. The glomerular filtration barrier is affected by many different metabolic ...
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The normal phenotype of the glomerular filtration barrier (GFB) and the mechanisms that underlie it have intrigued physiologists, microvascular biologists, and renal physicians for decades, especially because, in health, the multilayered barrier differentially restricts the passage of molecules of various sizes, shapes, and charges. Although poorly permeable to large lipid–insoluble or anionic ...
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ژورنال
عنوان ژورنال: International Physiology
سال: 2020
ISSN: 2347-1506,2455-6262
DOI: 10.21088/ip.2347.1506.8120.4